(Hematopoietic) PGDS protein, also known as Glutathione-Dependent PGD Synthase, is a protein that in humans is encoded by the HPGDS gene.
Gluthionine-dependent Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. As a type of Prostaglandin-D synthase, it catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.