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3',5'-cyclic-AMP phosphodiesterase

3′,5′-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3′,5′-cyclic-AMP 5′-nucleotidohydrolase. It catalyses the following reaction

adenosine 3′,5′-cyclic phosphate + H<sub>2</sub>O AMP

This enzyme requires Mg<sup>2+</sup> or Mn<sup>2+</sup> for activity.

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