Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.
PBX2 has been shown to interact with HOXA9.