An oxaprostaglandin is a type of prostaglandin with one carbon atom replaced by an oxygen atom. These are found in nature and have also been produced synthetically.
A 13-oxaprostaglandin analogue has been shown to treat glaucoma and ocular hypertension. The 11-oxa prostaglandin analogue AL-12182 1 has potent topical ocular hypotensive activity. 7-Oxa-13-prostynoic acid promotes erythrocyte lysis and dissolution of erythrocyte membranes.
11-Oxaprostaglandin f<sub>2</sub>ñ and 11-oxaprostaglandin f<sub>2</sub>ò have been synthesized from <small>D</small>-glucose.