The Owens River course includes headwaters points near the Upper San Joaquin Watershed, reservoirs and diversion points (e.g., for the Los Angeles Aqueduct), and the river's mouth at Owens Lake. The river drains the Crowley Lake Watershed (USGS HUC 18090102) of and the north portion of the Owens Lake Watershed (USGS HUC 18090103) of .