Ouve-Wirquin (; ; ) is a commune in the Pas-de-Calais department in the Hauts-de-France region of France.
Ouve-Wirquin lies about 10 miles (16 km) southwest of Saint-Omer, on the junction of the D225 and the D341, the route of the Roman road the Chausée Brunehaut. The river Aa flows through the commune.
The Chemin de fer d'Anvin ÃÂ Calais opened a railway station at Ouve-Wirquin in 1881. The railway was closed in 1955.