This is a list of winners and nominees of the Primetime Emmy Award for Outstanding Guest Actor in a Comedy Series. Prior to 1988 the category was not gender specific, thus was called Outstanding Guest Performer in a Comedy Series. These awards, like the other "Guest" awards, are not presented at the Primetime Emmy Award ceremony, but rather at the Creative Arts Emmy Award ceremony.
Beginning with the 77th Primetime Emmy Awards, performers are no longer eligible in guest acting categories if they were previously nominated for a lead or supporting award for playing the same character role in the same series.
Nathan Lane has received the most nominations in this category with 7, winning once for the Hulu comedy series Only Murders in the Building in 2022. Mel Brooks has received the most wins in this category for his role in the NBC comedy series Mad About You in 1997, 1998, and 1999.