Otter Creek is a long second-order tributary to the Niobrara River in Holt County, Nebraska.
Otter Creek rises on the Ash Creek divide about southwest of School No. 249 in Holt County and then flows northwest into Rock County and then northeast back to Holt County to join the Niobrara River about south-southeast of School No. 19.
Otter Creek drains of area, receives about of precipitation, and is about 4.69% forested.