Otis is a Statutory Town in Washington County, Colorado, United States. The population was 511 at the 2020 census.
Otis was established in 1882 as a construction campsite for workers building the Burlington & Missouri River rail line from Lincoln Nebraska to Denver, Colorado. According to tradition, the community was named after W. O. Otis, a pioneer settler. The post office opened in 1886 and the town was platted in 1887.
Otis is located at (40.150645, -102.962521).
According to the United States Census Bureau, the town has a total area of , all of it land.
According to the Köppen Climate Classification system, Otis has a semi-arid climate, abbreviated "BSk" on climate maps.