Otay Mesa Detention Center is a minimum/medium security federal prison for women, managed by CoreCivic under contract with the United States Marshals Service and U.S. Immigration and Customs Enforcement (ICE). The facility is situated in the San Ysidro Mountains foothills of Otay Mesa overlooking the U.S.-Mexico border.
The Otay Mesa site is shared with some other properties related to law enforcement:
In the 2025 film One Battle After Another, a far-left revolutionary group breaks immigrants out of the center. The scene was filmed at the center itself, and to do so, the filmmakers received approval from the city of Otay Mesa, the San Diego County government, U.S. Border Patrol, the Department of Homeland Security, California Highway Patrol, and Caltrans.