Osredek pri Krmelju () is a settlement northwest of Krmelj in the Municipality of Sevnica in central Slovenia. The area is part of the historical region of Lower Carniola. The municipality is now included in the Lower Sava Statistical Region. It includes the hamlets of Rupa, Radvanca, Dobovec, Gabrje, Komatca, Oplaz, Kij, and Prinà ¡tal.
The name of the settlement was changed from Osredek to Osredek pri Krmelju in 1953. The hamlet of Prinà ¡tal was also known as Primà ¡tal () in older sources.
The local church is dedicated to Saints Primus and Felician and belongs to the Parish of à  entjanà ¾. It dates to the 17th century.