Osama Yousef Al-Khalaf (; born December 26, 1996) is a Saudi professional footballer who plays as a midfielder or a right back for Al-Adalah on loan from Neom.
On 20 July 2022, Al-Khalaf joined Al-Fayha on a two-year deal.
On 2 July 2024, Al-Khalaf joined Saudi First Division League club Neom on a free transfer. On 1 February 2025, Al-Khalaf joined Al-Orobah on loan. On 10 September 2025, Al-Khalaf joined Al-Adalah on loan.