The Orlov-Denisov family () was the Russian noble family of Don Cossacks origin.
Members of the family held the title of Count in the Russian Empire since 1801. In honour of Vasily Orlov-Denisov's grandfather Fedor Petrovich Denisov he added the name of Denisov family to his own, becoming Orlov-Denisov on 26 April 1801.