Orio Litta (Lodigiano: ) is a comune (municipality) in the Province of Lodi in the Italian region Lombardy, located about southeast of Milan and about southeast of Lodi. As of 31 December 2004, it had a population of 1,982 and an area of .
Orio Litta borders the following municipalities: Livraga, San Colombano al Lambro, Ospedaletto Lodigiano, Senna Lodigiana, Chignolo Po, Calendasco, Monticelli Pavese.
On November 21, 1765 a rabid wolf attacked the residents of Orio Litta, biting sixteen people before being killed. Fourteen of the victims died after being taken to the Lodi hospital.