Oqdaryo District () is a district of Samarqand Region in Uzbekistan. The capital lies at the town Loyish. It has an area of and its population is 161,700 (2021 est.).
The district consists of 10 urban-type settlements (Loyish, Dahbed, Avazali, Bolta, Qirqdarxon, Kumushkent, Oytamgûali, Oqdaryo, Yangiqoûrgûon, Yangiobod) and 6 rural communities.