Opodepe is a municipality in the state of Sonora in north-western Mexico.
The municipal seat is Opodepe.
The municipal area is 2,804.25 km<sup>2</sup> with a population of 2,842 registered in 2000.
Neighboring municipalities are BenjamÃÂn Hill, Santa Ana, Cucurpe, Arizpe, Banámichi, San Felipe de Jesús, Carbó, Rayón and Trincheras.