Ophiem is an unincorporated community in Lynn Township, Henry County, Illinois, United States. As of the 2020 census, Ophiem had a population of 123.
It was founded in 1850 by Johannes and Carl Johan Samuelson, who named it "Opphem", after their family farm in Sweden.
A post office was established in 1871.
Ophiem first appeared as a census designated place in the 2020 U.S. census.
It is in the Alwood Community Unit School District 225.