Ophain-Bois-Seigneur-Isaac () is a village of Wallonia and a district of the municipality of Braine-l'Alleud, located in the province of Walloon Brabant, Belgium.
It was a municipality in its own right before the fusion of the Belgian municipalities in 1977.
Some popular spots to see are La grange, Ferme du Moulin ÃÂ Eau, Carrefour express, Place d'Ophain, Chez Detant, and Chateau Bois Seigneur.