Oksana Khvostenko () (born 27 November 1977 in Chernihiv) is a Ukrainian biathlete. She is a multiple medalist at the World Championships. In 2008 together with Andriy Deryzemlya she won World Team Challenge.
Khvostenko tested positive for ephedrine at a post event doping control at the Biathlon World Championships 2011 where the Ukrainian team had finished second in the Women's Relay. The team was later disqualified because of the anti-doping rule violation and Khvostenko received a one-year ban from sport, commencing on 13 March 2011.
Since 2001, she is married to Ukrainian biathlete Vyacheslav Derkach.