Ohoopee is an unincorporated community and census-designated place (CDP) in Toombs County, in the U.S. state of Georgia.
The 2020 Census listed a population of 29.
A post office called Ohoopee was established in 1875, and remained in operation until 1953. The community took its name from the nearby Ohoopee River.
The Georgia General Assembly incorporated Ohoopee as a town in 1907. The town's municipal charter was repealed in 1995.
Ohoopee was first listed as a census designated place in the 2020 United States census.