State Route 126 (SR 126) is a state route starting at the Indiana state line, at a split with SR 129 near Scipio, and ending east of Cincinnati at an intersection with U.S. Route 50 (US 50) in Milford. SR 126 is locally known for comprising most of Ronald Reagan Cross County Highway.
Prior to the completion of Ronald Reagan Cross County Highway in 1997, the central portion of SR 126 between Ross and Montgomery consisted of West Kemper Road, Springfield Pike (SR 4), Glendale Milford Road, Kenwood Road, and Cooper Road. On October 28, 1997, the Ohio Department of Transportation (ODOT) took over Ronald Reagan Highway, except for the segment west of Colerain Avenue. SR 126 was rerouted over the highway, while Kemper, Glendale Milford, Kenwood, and Cooper roads were returned to local authorities.