Ofahoma is an unincorporated community in Leake County, Mississippi, United States. Ofahoma is located along Mississippi Highway 16 west of Carthage.
Ofahoma is a name derived from the Choctaw language meaning "Red Dog"; this name most likely was applied to a local Choctaw warrior.
The community is located on the Yockanookany River and in 1900 had a population of 106.
A post office operated under the name Ofahoma from 1866 to 1982.