Odra-Pisuerga is a comarca (county, but without administrative roles) located in the west of the province of Burgos, in the autonomous community of Castile and León, Spain. It is bounded by the west and south-west by the province of Palencia, south-east by the Arlanza comarca, west by the Alfoz de Burgos and north by the Páramos comarca.
The comarca is bounded in the west by the Pisuerga river, and in the east by its affluent, the Odra and Pisuerga river, giving name to the region.