Odessa is a census-designated place (CDP) in Odessa Township, Buffalo County, Nebraska, United States. It is part of the Kearney, Nebraska Micropolitan Statistical Area. As of the 2020 census, Odessa had a population of 132.
It was named after Odesa, Ukraine.
Odessa is located in southwestern Buffalo County along U.S. Route 30, west of Kearney, the county seat. It is west to Elm Creek via US 30. Interstate 80 passes to the south of Odessa, with access via Exit 263 (Highway 10B/Odessa Road).
According to the United States Census Bureau, the Odessa CDP has a total area of , all land.