Octadecyltrimethoxysilane (OTMS) is an organosilicon compound. This colorless liquid is used for preparing hydrophobic coatings and self-assembled monolayers. It is sensitive toward water, irreversibly degrading to a siloxane polymer. It places a C<sub>18</sub>H<sub>39</sub>SiO<sub>3</sub> "cap" on oxide surfaces. The formation of OTMS monolayers is used for converting hydrophilic surfaces to hydrophobic surfaces, e.g. for use in certain areas of nanotechnology and analytical chemistry.