Orexin receptor type 1 (Ox1R or OX<sub>1</sub>), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.
The orexin 1 receptor (OX<sub>1</sub>), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX<sub>1</sub> selectively binds the orexin-A neuropeptide. It shares 64% identity with OX<sub>2</sub>.