OSU-6162

OSU-6162, also known as PNU-96391, is a compound which acts as a partial agonist at both dopamine D₂ receptors and 5-HT_2A receptors. It acts as a dopamine stabilizer in a similar manner to the closely related drug pridopidine, and has antipsychotic, anti-addictive and anti-Parkinsonian effects in animal studies. Both enantiomers show similar activity but with different ratios of effects, with the (S) enantiomer (–)-OSU-6162 that is more commonly used in research, having higher binding affinity to D₂ but is a weaker partial agonist at 5-HT_2A, while the (R) enantiomer (+)-OSU-6162 has higher efficacy at 5-HT_2A but lower D₂ affinity.

See also

• List of investigational hallucinogens and entactogens
• List of investigational Parkinson's disease drugs
• Non-hallucinogenic 5-HT_2A receptor agonist
• 3-Phenylpiperidine
• Flumexadol
• LPH-5
• PF-219,061

References