Nyzhni Sirohozy Raion () was one of the 18 administrative raions (a district) of Kherson Oblast in southern Ukraine. Its administrative center was located in the urban-type settlement of Nyzhni Sirohozy. The raion was abolished on 18 July 2020 as part of the administrative reform of Ukraine, which reduced the number of raions of Kherson Oblast to five. The area of Nyzhni Sirohozy Raion was merged into Henichesk Raion. The last estimate of the raion population was
At the time of disestablishment, the raion consisted of one hromada, Nyzhni Sirohozy settlement hromada with the administration in Nyzhni Sirohozy.
As of the 2001 Ukrainian census, the raion had a population 19,823, which decreased to 15,033 in early 2022. The population is overwhelmingly Ukrainian, but also has significant minority groups, which include Russians, Meskhetian Turks, Ukrainian Kurds, Koryo-saram and Moldovans. The exact ethnic and linguistic composition was as follows: