The North Branch Meduxnekeag River is a river in Aroostook County, Maine and Carleton County, New Brunswick. From the outlet of a small pond () in Maine Township 8, Range 3, WELS, the river runs about northeast, south, and east to the CanadaâÂÂUnited States border, crossing into Canada at . It runs about southeast to its confluence with the Meduxnekeag River in Wakefield, NB.