Nisa, officially the Notable Town of Nisa, is a municipality in Portalegre District in Portugal. The population in 2011 was 7,450, in an area of 575.68 km<sup>2</sup>.
The present Mayor is Maria Idalina Alves Trindade (PS - Partido Socialista). The municipal holiday is Easter Monday.
In addition, it lends its name to Queijo de Nisa, a Portuguese sheep cheese with a protected designation of origin (PDO).
Administratively, the municipality is divided into 7 civil parishes (freguesias):