Nipmuc Regional High School is a public high school in Upton, Massachusetts, United States, part of the Mendon-Upton Regional School District.
Nipmuc Regional High School is located on a fifty-acre wooded lot in Upton, Massachusetts, in the Blackstone Valley region of the state. It serves the towns of Mendon and Upton through a cooperative arrangement established in 1961. The school was named after the Nipmuc indigenous people of the area. In addition to Nipmuc Regional, there are three other schools in the Mendon-Upton Regional School District: Miscoe Hill Middle School, Clough Elementary School (Mendon), and Memorial Elementary School (Upton). In 2024, the year-round populations of the two towns were 6,228 (Mendon) and 8,000 (Upton).
Nipmuc Regional High School sports include mixed cheer leading, cross country, football, Golf (men), soccer, field hockey, baseball, volleyball, lacrosse, track (indoor/outdoor), hockey, basketball, wrestling and swimming. They are in the Dual Valley Conference (a conference made up entirely of division 5 schools, with the exception of Nipmuc) and their sports range from division 1 to division 4. The boys' soccer team won the Division 3 State Championship in 2017. The girlsâ soccer team won the Division 3 MIAA State Championship in 2024. The following year they came in second loosing 1-0 to the Medfield team.
The participation rate for Nipmuc is 68%