Nikolskoye () is a rural locality (a selo) and the administrative center of Nikolskoye Rural Settlement, Ust-Kubinsky District, Vologda Oblast, Russia. The population was 451 as of 2002. There are 8 streets.
From 1885 to 1933, the local hospital was run by the Belarusian physician Nadezhda Bantle, who according to locals reformed it into the most advanced hospital in the region.
The distance to Ustye is 33 km. Filenskoye is the nearest rural locality.