Nicolai Mandrîcenco (, Mykola Mandrychenko; born 12 March 1958) is a Moldovan professional football manager and former footballer. He has Ukrainian citizenship.
Since August 2014 he is the head coach of Moldavian football club FC Dinamo-Auto Tiraspol.
He has two sons Constantin Mandrîcenco and Dmitri Mandrîcenco both born in Moldova and who are also footballers.