Newtonville is an unincorporated community and census-designated place in Hammond Township, Spencer County, in the U.S. state of Indiana.
Newtonville was platted in 1865 by Bezaleel Newton and others.
A post office was established at Newtonville in 1860, and remained in operation until it was discontinued in 1984.
The United States Census Bureau defined Newtonville as a census designated place in the 2022 American Community Survey.