Neuville-sur-Brenne (, before 1987: Neuville), (literally "Neuville on Brenne"), is a commune in the Indre-et-Loire department in central France.
The commune lies on the Brenne River, a tributary of the Cisse, and is situated about 7 km Northwest of Château-Renault. It is a small rural community known for its agricultural landscape and its parish church of Saint-Martin.