The neuromedin U receptors are two G-protein coupled receptors which bind the neuropeptide hormones neuromedin U and neuromedin S. There are two subtypes of the neuromedin U receptor, each encoded by a separate gene (, ).
Neuromedin U is an agonist at both the NMU<sub>1</sub> and NMU<sub>2</sub> subtypes, while neuromedin S is selective for NMU<sub>2</sub>, and is a more potent agonist at this subtype than neuromedin U. Several other peptide and non-peptide ligands are also available for the NMU receptors.