Athletes from the former Netherlands Antilles competed at the 2011 Pan American Games in Guadalajara, Mexico from October 14 to 30, 2011, about one year after the dissolution of the country. Hubert Isenia was the Chef de mission of the team. The team consisted of eleven athletes in six sports.
Athletes from the Netherlands Antilles qualified one male cyclist in road cycling.
Athletes from the Netherlands Antilles qualified one athlete in the 61 kg women's category.
Athletes from the Netherlands Antilles qualified three boats and three athletes in the sailing competition.
Athletes from the Netherlands Antilles qualified two shooters.
Athletes from the Netherlands Antilles qualified two swimmers.
The Netherlands Antilles received a wildcard to send one male taekwondo athlete.