Nestos () is a municipality in the Kavala regional unit, East Macedonia and Thrace, Greece. The seat of the municipality is the town Chrysoupoli. The municipality has an area of 678.831 km<sup>2</sup>. It was named after the river Nestos.
The municipality Nestos was formed at the 2011 local government reform by the merger of the following 3 former municipalities, that became municipal units:
The province of Nestos () was one of the provinces of the Kavala Prefecture. It had the same territory as the present municipality. It was abolished in 2006.