Negro Creek is a long 2nd order tributary to Hyco Creek in Caswell County, North Carolina.
Negro Creek rises about 2.5 miles southeast of Baynea, North Carolina in Alamance County, and then flows northeasterly into Caswell County to join Hyco Creek about 2 miles south-southeast of Hightowers.
Negro Creek drains of area, receives about 46.5 in/year of precipitation, has a topographic wetness index of 362.36, and is about 54% forested.