The National Security Bureau (), officially the National Security Bureau of the Central Command of the Syrian Regional Branch (), was a Ba'ath Party bureau which coordinated the work of Syria's intelligence and security agencies and advised the General Secretary prior to the 2024 fall of the Assad regime. The last head of the National Security Bureau was Kifah Moulhem.
In the past, individual intelligence and security agencies had a significant degree of independence and generally reported directly to the president of Syria. Since 2023, the Bureau had been conducting a set of restructuring measures in the intelligence and security services, including merging some branches. The main goal of the changes was to amend the powers of intelligence and security services, remove them from some state institutions and develop coordination among the agencies.