Mir Naseer Khan Khoso was a Chhutani Khoso from Madadpur village in the Thul Sub Division of Jacobabad District. He was a well known politician and became a Member of Provincial Assembly (MPA) in 1997 for the first time and became Minister of Sindh. In 2002 he was elected as MPA for the second time.
He has four sons, namely Abdul Hafeez, Mahfuz-ur-Rehman, Anees-ur-Rehman and Muhammad Sadiq
He died on 24 December 2020, and is buried in Mir Nawab Khan Khoso, a village located in Jacobabad.