Mohamed Naoufel Khacef (; born 27 October 1997) is an Algerian professional footballer who plays as a left-back for CR Belouizdad.
In 2020, he played for Girondins de Bordeaux B. On 3 September 2020, Khacef joined Portuguese club Tondela. On 20 July 2023, he joined Turkish club Gaziantep. On 22 January 2024, Khacef joined CR Belouizdad.
In July 2015, Khacef was called up to the Algeria under-20 national team.
He made his debut for Algeria national football team on 29 March 2021 in a 2021 Africa Cup of Nations qualifier against Botswana.