Nanticoke Creek is a river in Broome County, New York. It is approximately long, emptying into the Susquehanna River in Endicott, New York. It flows from its source above and through Nanticoke Lake in Lisle, New York, through the towns of Nanticoke, Maine, and Union.
In December 2020, the creek overflowed its banks and flooded part of the En-Joie Golf Club in Endicott, New York.
Parts of the creek near Maine, New York are suitable for fishing.