NGC 251 is a spiral galaxy in the constellation of Pisces. Its velocity with respect to the cosmic microwave background for is , which corresponds to a Hubble distance of . Additionally, six non redshift measurements give a distance of . It was discovered on October 15, 1784, by German-British astronomer William Herschel.
According to I.D. Karachentsev, NGC 251 forms an isolated galaxy pair with UGC 477.
One supernova has been observed in NGC 251: SN 2023rky (type II, mag. 18.6) was discovered by the Zwicky Transient Facility on 6 September 2023.