IκBα

IκBα (<u>n</u>uclear <u>f</u>actor of <u>k</u>appa light polypeptide gene enhancer in <u>B</u>-cells <u>i</u>nhibitor <u>a</u>lpha; NFKBIA) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.

Disease linkage

The gene encoding the IκBα protein is mutated in some Hodgkin's lymphoma cells; such mutations inactivate the IκBα protein, thus causing NF-κB to be chronically active in the lymphoma tumor cells and this activity contributes to the malignant state of these tumor cells.

Interactions

IκBα has been shown to interact with:

• BTRC,
• C22orf25,
• CHUK,
• DYNLL1,
• G3BP2,
• Heterogeneous nuclear ribonucleoprotein A1,
• IKK2,
• NFKB1,
• P53,
• RELA,
• RPS6KA1,
• SUMO4, and
• Valosin-containing protein.

References

Further reading

External links

• OMIM entries on Ectodermal Dysplasia, Anhidrotic, with T-cell Immunodeficiency