Malate dehydrogenase (decarboxylating)

Malate dehydrogenase (decarboxylating) () or NAD-malic enzyme (NAD-ME) is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (S)-malic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are pyruvic acid, carbon dioxide, and reduced NADH.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD⁺ oxidoreductase (decarboxylating). This enzyme participates in pyruvate metabolism and carbon fixation. NAD-malic enzyme is one of three decarboxylation enzymes used in the inorganic carbon concentrating mechanisms of C₄ and CAM plants. The others are NADP-malic enzyme and PEP carboxykinase.

See also

• Malate dehydrogenase (oxaloacetate-decarboxylating) which performs the same reaction

References