NA-221 Tando Muhammad Khan () is a constituency for the National Assembly of Pakistan.
General elections were held on 10 October 2002. Naveed Qamar of PPP won by 53,075 votes.
General elections were held on 18 February 2008. Naveed Qamar of PPP won by 84,041 votes.
General elections were held on 11 May 2013. Naveed Qamar of PPP won by 100,095 votes and became the member of National Assembly.
General elections were held on 25 July 2018.
Elections were held on 8 February 2024. Naveed Qamar won the election with 111,738 votes.