NA-191 Jacobabad-cum-Kashmore () is a constituency for the National Assembly of Pakistan. It comprises the entirety of Kashmore District. It was created in the 2018 delimitation from the merger of the old constituencies of NA-209 and NA-210.
General elections were held on 25 July 2018.
General elections were held on 8 February 2024. Ali Jan Mazari won the election with 103,548 votes.