In enzymology, a N-acylmannosamine 1-dehydrogenase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are N-acyl-D-mannosamine and NAD<sup>+</sup>, whereas its 3 products are N-acyl-D-mannosaminolactone, NADH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is N-acyl-D-mannosamine:NAD<sup>+</sup> 1-oxidoreductase. Other names in common use include N-acylmannosamine dehydrogenase, N-acetyl-D-mannosamine dehydrogenase, N-acyl-D-mannosamine dehydrogenase, and N-acylmannosamine dehydrogenase.