N,N-Diformylmescaline, also known as N,N-diformyl-3,4,5-trimethoxyphenethylamine, is a possible psychedelic drug of the phenethylamine and scaline families related to mescaline. It is the N,N-diformyl derivative of mescaline. The compound has been found to be chemically unstable under acidic or basic conditions, breaking down into N-formylmescaline and then into mescaline. Relatedly, it is thought that N,N-diformylmescaline may act as a prodrug of mescaline in vivo. The chemical synthesis of the compound has been described. It was encountered as a possible novel designer drug in 2020 and this was reported in 2022. N,N-Diformylmescaline itself is not known to be naturally occurring, but N-formylmescaline is known to occur naturally in trace amounts in peyote. It is not a controlled substance in Canada as of 2025.